Pegaptanib Sodium versus Pegaptanib Sodium Combined with Macular Laser Photocoagulation or Laser Alone for Diabetic Macular Edema
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Pegaptanib Sodium versus Pegaptanib Sodium Combined with Macular Laser Photocoagulation or Laser Alone for Diabetic Macular Edema
Purpose. To report the outcomes after primary intravitreal pegaptanib sodium in patients with diabetic macular edema (DME). Methods. We conduced a retrospective analysis of eyes with DME treated with primary intravitreal pegaptanib sodium (Macugen) (intravitreal pegaptanib group). The results were compared with the ones of eyes treated with intravitreal pegaptanib sodium associated with macular...
متن کاملIntravitreal bevacizumab versus combined bevacizumab-triamcinolone versus macular laser photocoagulation in diabetic macular edema.
PURPOSE To evaluate the additive effect of triamcinolone to bevacizumab in comparison to standard macular laser photocoagulation versus bevacizumab in the management of diabetic macular edema (DME). METHODS In a prospective, randomized clinical trial, 130 eyes of 110 patients with type 2 diabetes with DME were included. Eligible eyes were randomly assigned to 1.25 mg intravitreal bevacizumab ...
متن کاملPopulation pharmacokinetics of pegaptanib sodium (Macugen®) in patients with diabetic macular edema
OBJECTIVE Population pharmacokinetic modeling of pegaptanib was undertaken to determine influence of renal function on apparent clearance. METHODS In a randomized, double-masked multicenter trial, intravitreal pegaptanib (0.3, 1.0, or 3.0 mg/eye) was administered in patients with diabetic macular edema every 6 weeks for 12-30 weeks. A one-compartment model with first-order absorption, distrib...
متن کاملrandomized trial of intravitreal bevacizumab alone or combined with triamcinolone versus macular photocoagulation in diabetic macular edema
purpose: to compare the results of intravitreal bevacizumb (ivb) injection alone or in combination with intravitreal triamcinolone acetonide (ivt) versus macular laser photocoagulation (mpc) as primary treatment of diabetic macular edema (dme). methods: in this randomized clinical trial, 150 eyes of 129 patients with clinical dme and no previous treatment were enrolled. the eyes were randomly a...
متن کاملIntravitreal pegaptanib for the treatment of ischemic diabetic macular edema
PURPOSE Pegaptanib has been shown to be effective in treating diabetic macular edema (DME). In the original Phase II/III trial, however, patients with macular ischemia were excluded. In this study, we treated patients with ischemic DME. METHODS Macular ischemia was defined as a 30% increase in the area of the foveal avascular zone (FAZ) at 45 seconds on fundus fluorescein angiography. In addi...
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ژورنال
عنوان ژورنال: Journal of Ophthalmology
سال: 2009
ISSN: 2090-004X,2090-0058
DOI: 10.1155/2009/672178